Intrapleural fibrinolytic therapy for pleural infection

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Intrapleural Fibrinolytic Therapy in Loculated Effusions

Loculated pleural effusions are most commonly due to complicated parapneumonic effusions and empyema followed by tubercular pleural effusions and empyema, hemothorax and malignant effusions. Loculations develop due to delayed initiation and inappropriate use of antibiotics and, delayed initiation of pleural space drainage. The presence of loculations and thick viscous fluid leads to failed pleu...

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A Five-Year Study of Intrapleural Fibrinolytic Therapy in Loculated Pleural Collections.

BACKGROUND Pleural fluid loculations due to complicated parapneumonic effusion (CPE), empyema, tubercular effusion and traumatic hemothorax can be managed either by video-assisted thoracoscopic surgery (VATS) or intrapleural ibrinolytic therapy (IPFT). The former is more invasive, not easily available and is also more expensive. On the other hand, IPFT is less invasive, cheaper, easily accessi...

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Intrapleural fibrinolytic therapy (IPFT) in loculated pleural effusions—analysis of predictors for failure of therapy and bleeding: a cohort study

OBJECTIVES To assess risk factors associated with failure and bleeding in intrapleural fibrinolytic therapy (IPFT) for pleural effusions. DESIGN Retrospective case series. SETTING Two tertiary-care centres in North America. PARTICIPANTS We identified 237 cases that received IPFT for the treatment of pleural effusions. Data for 227 patients were compiled including demographics, investigati...

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U.K. Controlled trial of intrapleural streptokinase for pleural infection.

BACKGROUND Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase. METHODS In this double-blind trial, 454 patients with pleur...

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Intrapleural streptokinase: the answer to community acquired pleural infection?

Approximately 40% of patients with community acquired prevent surgery it must be initiated before the fibrino-purulent stage is advanced and organisation occurs. pneumonia develop a parapneumonic effusion, despite the Placement of the catheter under ultrasound guidance availability of appropriate antibiotics. 1 This effusion may allows better positioning, particularly in multiloculated become s...

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ژورنال

عنوان ژورنال: Pulmonary Pharmacology & Therapeutics

سال: 2007

ISSN: 1094-5539

DOI: 10.1016/j.pupt.2006.08.001